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10.1002/adma.201904197 50 LimJ.LamY
however, human safety profiles remain undefined
NAC in Animal Studies of Asthma In a rat model of asthma, oral pretreatment with NAC reduced airway hyperresponsiveness, decreased lipid peroxidation and oxidized glutathione levels, and lowered the TNF, inducible nitric oxide (NO) synthase, ICAM-1, and mucin MUC5AC expressions [138]
Thus, in the canonical GPX4-regulated ferroptotic pathway, the inhibition of two cellular components, GPX4 and system XC cystine/glutamate antiporter, by RSL3 and erastin, respectively, triggers ferroptotic cell death (7,23)
