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In-depth research has revealed that the TGF-1/Smad signaling route is widely acknowledged for its significant role in the development of renal fibrosis in DKD
Currently, certain drugs that alleviate oxidative stress and inflammation by eliminating ROS, such as thioproline and N-acetylcysteine, have been applied in IBD clinical treatments (82), providing valuable references for developing novel ferroptosis inhibitors to improve intestinal diseases
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