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However, the changes induced by -Glu-Ser-Gly and glutathione sulfinic acid were exceptionally distinct among all of them

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From the article: We have identified a specific signal that is generated in visceral fat, released into the blood that gets through the blood brain barrier and into the brain where it activates microglia and impairs cognition. Visceral fat as the ring leader: They looked further and found that just transplanting the visceral fat caused essentially the same impact as obesity resulting from a high-fat diet, including significantly increasing brain levels of interleukin-1 beta and activating microglia