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Current Topics in Medicinal Chemistry;22(18):1472-1484 17

At which exact age depends upon how steady your weight is throughout your life, your genetic predisposition, and how carefully you protect your skin from sun and other environmental damage

In terms of treatment, although the rashes in the aforementioned cases improved after discontinuing the supplements, systemic treatment with oral corticosteroids and other medications was still required to significantly alleviate the symptoms

Giving it by IV specifically to lighten skin is an off-label, poorly evidenced use, and bodies including the US FDA have warned about injectable skin-whitening products