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This stabilized FOXO4 binds to the transactivation domain 2 (TAD2) of p53, sequestering it in the nucleus and preventing it from triggering mitochondrial-mediated apoptosis (Frontiers, 2025)

Peden College of Public Health, Medical, and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia Amy E

TumorAssociated Macrophages Ginsenoside Rb1 promotes macrophage polarization toward the M1 phenotype with antitumor functions by regulating the NFB signaling pathway, while simultaneously enhancing phagocytic activity [225]
