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and Tier 3 for novel synthetic peptides requiring full phased clinical development and standard NDA or BLA pathways
Given that NNMT has been reported to be a primary metabolic enzyme[36] and a major clearance pathway for intracellular NA,[15] it is likely that these small molecules are directly and selectively inhibiting the conversion of NA to 1-MNA
Remaining telopeptide lysine residues can be hydroxylated through LH isoforms, possibly LH2 (Gjaltema and Bank, 2017
2021 Apr 22;12:673708
