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The above enzymes are involved in counteracting the generated ROS when exercising: SOD by converting superoxide anions to hydrogen peroxide and then this hydrogen peroxide is broken down into water and oxygen by CAT thus reducing the oxidative damage ( Evidence indicates that dietary supplementation with PBPs significantly augments these enzymatic activities ( Antioxidants: exercise promotes consumption and availability: the presence of exercise also means that there is an increased need for antioxidants, as regular physical activity augments the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) ( 5.3 Protection of mitochondrial function Mitochondria are the primary sites of cellular energy production

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Some of these inhibitors have dual inhibitory effects on mTOR and PI3K due to the similarity of their kinase domain structures (105)

MM, Multiple myeloma MC38(C57BL/6J), Tumor-bearing mice inoculated with MC38