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doi:10.1007/s12020-017-1446-7

Elevated IGF-1 and Cancer Risk IGF-1 is a growth signal

(287) demonstrated that inflammation of the muscularis externa of the small intestine caused by manipulation following laparotomy caused the upregulation of C-C chemokine family ligand (CCL)2 (monocyte chemoattractant protein-1) and colony-stimulating factor (CSF)-1 by enteric glia that promote the recruitment of monocytes to the muscularis and their differentiation into pro-resolving macrophages leading to tissue recovery

This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse