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Discontinuation leads to gradual weight regain over 612 months, indicating that tirzepatide addresses the underlying biology driving excess weight rather than producing permanent metabolic resetting
Ten to 15% of LDL receptor mutations are large deletions or insertions, which may be missed by routine DNA sequencing
The number of included studies was limited, most being small-sample and short-term clinical trials, and the lack of large-scale, robust RCTs restricts the strength of the conclusions
