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Connect mitochondrial dysfunction, gut health, toxic exposures, and hormonal imbalances to the clinical picture of CKD

The brain is particularly susceptible to oxidative stress due to its high oxygen demand, abundance of high-redox-active metals (such as iron and copper), and vulnerability of polyunsaturated fatty acids to oxidative damage, while the number of antioxidant factors is relatively limited [174, 175]

That includes irritation and inflammation on your skin

As with the stimulant drugs, the main impact of other drugs of abuse on dopaminergic transmission occurs in target regions of the dopaminergic afferents (i.e., striatum and frontal cortex)