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I believe this is very conservative given the Phase 2b PYR-210 clinical trial showed a 57% treatment effect and the hurdle for success in the current Phase 3 PIONEER trial is only 28%

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Spirulina is not a good source of B12 and only contains B12 analogues Because vitamin B12 is water-soluble it's extremely hard to overdose, and because the body is quite inefficient at absorbing B12, supplements often contain 10,000% RDA, sometimes even 100,000% RDA, to try and ensure the body actually absorbs some of it