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Muscle mass as a fraction of body weight decreases with age, which is why age appears in the Cockcroft-Gault equation

doi: 10.3389/fphys.2026.1760997 Received 04 December 2025 Revised 18 February 2026 Accepted 23 February 2026 Published 20 March 2026 Volume 17 - 2026 Edited by Lars Knudsen, Hannover Medical School, Germany Reviewed by Svetlana Guryanova, Institute of Bioorganic Chemistry (RAS), Russia Ana Maria Jaramillo, University of Kansas Hospital, United States Updates Copyright 2026 Costello and Birket

doi: 10.3389/fmed.2022.791914 Received 07 December 2021 Accepted 12 April 2022 Published 29 April 2022 Volume 9 - 2022 Edited by Nahal Mansouri, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland Reviewed by Sermet Sezigen, University of Health Sciences, Turkey