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Determining drug dosage, timing, and mode of administration should begin with in vitro experiments, reference clinically established safe dosages, and integrate drug toxicology
Based on their structure, the AKR inhibitors are classified into three groups, (i) carboxylic acid derivatives such as epalrestat, tolrestat, ponalrestat, zopolrestat, and zenarestat
10.31083/j.jin2003078 41 KimK.ParkK
