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It's released in rhythmic pulses and the timing, frequency, and amplitude of those pulses determine whether ovulation happens at all
[1] The effects were even more pronounced in aged animals
Immunohistochemical and in situ hybridization studies have detected MC4R localization in various brain regions, including the hippocampus, paraventricular nucleus of the hypothalamus (PVN), Arc, ventromedial hypothalamus (VMH), amygdala, VTA, and NAc (Kishi et al., 2003
Y., Yang, J
