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Cytochrome P450 The cytochrome P450 isozymes, including CYP2E1, 1A2, and 3A4, which are present predominantly in the microsomes, or vesicles, of a network of membranes within the cell known as the endoplasmic reticulum, also contribute to alcohol oxidation in the liver

Furthermore, targeting regulators within the crosstalk itself, such as knocking down deltex E3 ubiquitin ligase 2 to stabilize NCOA4 and promote ferritinophagy, can mitigate cisplatin resistance in NSCLC (121)

HMOs also play significant roles in adult brain development and cognitive function

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy