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However, the impact of GSH itself, its role in B cell metabolism and B cell responses has so far been elusive
doi: 10.3109/15569527.2013.808658

This decrease in production can be due to a number of factors, including a decrease in the activity of enzymes needed for glutathione production, a decline in the level of nutrients needed for glutathione production, and damage to cells and tissues that impairs their ability to produce glutathione
