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While in one meta-analysis liver ultrasound was found to have a pooled sensitivity of 84.8% and specificity of 93.6% to detect hepatic steatosis of more than 20-30% (119), this literature is largely from liver clinics where disease severity is greater (i.e., more steatosis and better performance) but may not reflect the setting of primary care physicians or endocrinologists

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Under normal conditions, YAP regulates cell growth and repair, but in IPF, it becomes overactivated (Fig

The above explanations fit well with the observation that intracranial hypertension may be found in up to half of ME/CFS patients, most commonly in combination with joint hypermobility (Higgins et al., 2013