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Antibiotic therapy may reduce middle ear damage in some patients with acute OM (Venekamp et al) but in 60% of cases, the infection spontaneously clears without antibiotic intervention and without complications (Venekamp et al]

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ROS acts as upstream signals for NLRP3 inflammasome activation by upregulating the expression of key components, including NLRP3, pro-CASP1, and pro-IL1B [141]

Andr DM, Horimoto CM, Calixto MC, Alexandre EC, Antunes E
