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A decrease in the expression of the pro-ferroptotic proteins ACSL4, TFR1, and VDAC2/3 and a decrease in dihydroethidium (DHE) fluorescence, iron, malondialdehyde (MDA), and myeloperoxidase (MPO) were further observed in metformin-treated mice

Since dehydration is much more common across the population than overhydration, it is not advisable to decrease water intake in an attempt to treat edema or fluid retention unless specifically asked to do so by a doctor