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Common ions, like zinc (Zn 2+ ), magnesium (Mg 2+ ), iron (Fe 2+ /Fe 3+ ) and copper (Cu 2+ ), are co-factors of a variety of enzymes which play an important role in stabilizing enzyme conformation, transferring electrons, and connecting enzymes and substrates in enzymatic reactions (Valdez et al., 2014)

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Previous studies demonstrated that CoQ 10 protects retinal cells against oxidative stress in vitro and in vivo , as well as prevents retinal damage induced by acute IOP elevation or excitotoxicity in vivo