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Severe, recalcitrant, disabling psoriasis unresponsive to other therapies

Together, they create a supportive environment for optimal cellular function

The role of vitamin D in the treatment of allergic diseases has not been fully elucidated ( Table 3 ) (222)

Additionally, the IL-33/PAR2 signaling in bronchial epithelium augments the type 2 inflammation and airway hyperresponsiveness by promoting the interaction between airway epithelial and mast cells, which is discussed in detail in the Supplementary Data (see Supplementary Figure 2A )
