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4.1 Enzymatic pathway of ferroptosis 4.1.1 ACSL4/LPCAT3/LOX lipid metabolism pathway Among the three families of lipid oxidases, lipoxygenase is crucial to the enzymatic processes driving ferroptosis

Wellness and therapeutic metabolites found in food and botanicals when taken in their natural matrix are generally safe even for chronic consumption, with extremely low toxicity, presenting ease in uptake or breakdown by the body, having low retention, and presenting low potential for physiological dependency [583]

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The commercial Fe 3 O 4 nanoparticles, the carbon supports (C) synthesized via the similar process without Hb, the porous carbon supports (pC) obtained using bull serum albumin (BSA) as template and the heme-derived single-atom Fe-N 4 catalysts through pyrolysis (FeSAN) were synthesized as references (Supplementary Figs