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It was shown that miR-663 positively regulates OXPHOS subunit and assembly factor protein levels by direct stabilization of complex III assembly factor UQCC2 ( miR-663 through hypermethylation of its promoter, which leads to decreasing OXPHOS proteins levels and enzymatic activity and stability of supercomplexes, which promotes tumorigenesis ( Figure 6 Fatty Acid Metabolism Fatty acid metabolism includes catabolic and anabolic processes that involve triglycerides, phospholipids, steroid hormones, and ketone bodies

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First, even when the testicular synthesis of androgens is blocked, intraCaP androgen levels that are sufficient to activate AR can be achieved