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It's assuming oral bioavailability matches intravenous administration
The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle
Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation
The use of a single compound also provides unequivocal evidence of its efficacy, free from the confounding effects of other substances
