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Topical capsaicin is applied to the upper abdomen and may reduce the need for antiemetics.127129 Capsaicin may cause redirection of blood flow from the enteric system to the skin, leading to activation of TRPV1 receptors and reducing substance P.130 A randomized clinical trial examined topical capsaicin (0.1%) versus placebo cream applied to the abdomen and the authors reported a 46% reduction in nausea from the baseline in the capsaicin arm versus 24.9% in the placebo arm

coli cells in the stationary phase of 3.3 L mL 1 OD 600 1 (Volkmer and Heinemann, 2011)

Oct 2021;172:105836