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Following up on this clinical efficacy trial, we have begun a pragmatic cluster randomized trial that will examine the clinical effectiveness of the 5-Cog paradigm, including the critical aspect of integration of results with recommendations for follow-up in the EMR, in 22 primary care clinics as well as evaluate implementation issues and economic impact (NCT05515224)

Effects of rapamycin treatment on pancreatic fibrosis, cellular apoptosis and oxidative stress in experimental chronic pancreatitis model
The glymphatic system, most active during slow-wave or restorative sleep, is essential for facilitating clearance of metabolic waste (Reddy and van der Werf, 2020

doi:10.1016/j.ajem.2011.06.040
