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8,9 The receptor was eventually extracted and an initial understanding of how it worked emerged

Lyophilisation is a freeze-drying process that removes water from a sample while preserving its molecular structure

The affected patients may present loss of elasticity and tightness of the skin in a localized area, or it can be systemic, manifesting around the lips with microstomia, eating and speaking limitations, or in the fingers with sclerodactyly and vascular complications leading to functional impairment [94]

8,11 The protein adducts formed, specifically those of mitochondrial protein adducts, lead to oxidative injury and hepatocellular necrosis