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First, as the water freezes and expands, it can create micro-fractures in the glass vial or compromise the seal of the rubber stopper, potentially allowing contaminants in upon thawing

We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)