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However, in several cases the sulfonation reaction can lead to formation of a more active metabolite compared to the parent compound as is the case for the hair follicle stimulant minoxidil (Buhl et al., 1990) or the diuretic agent triamterene (Mutschler et al., 1983)
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As the hallmark roles for TrxR are to provide reducing power for RNR and antioxidant enzymes, one might first ask whether the metazoan transition was associated with novel replication- or antioxidant-demands, which might have been better served by the new TrxR
Advanced considerations for experienced researchers Once you have the fundamentals down, there are additional factors that can optimize your protocol
