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4 An estimated 1030% of adults have tinnitus, and the prevalence increases with age
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10.1038/s41579-023-00904-3 24 HuH.LinA.KongM.YaoX.YinM.XiaH.et al (2020)

It has been shown that tretinoin (retinoic acid) and its derivatives, isotretinoin, adapalene and tazarotene, may decrease pigmentation in vitro most probably via the induction of keratinocyte proliferation and epidermal turnover acceleration, rather than by acting directly on melanogenesis [145]