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Reviewer 2 This is a straightforward paper that addresses whether tamoxifen affects neurogenesis and whether there is any difference if it is given IP or orally

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Concluding Remarks The development of non-cytotoxic anti-CD38 antibodies and small molecules targeting the NADase enzymatic activity of CD38 may present as an important advancement in therapies for cancers and age-related diseases, but many important questions remain about CD38 biology and potential therapeutic uses (see outstanding questions)

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