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Book review: GABA and glutamate in the human brain

Therefore, an increase in tricarboxylic acid cycle/electron transport chain (TCA/ETC) activity due to an elevated supply of BHB may result in augmented production of reactive oxygen species, serving as a Tcell second messenger, hence amplifying Tcell immune capacity

Meanwhile, the upregulation of MDM2 suggests that the p53 signaling pathway may be inhibited, which to a certain extent reduces the ability of cells to repair DNA damage and may prompt cells to evade apoptotic mechanisms, further accelerating tumor progression

Biochemical and biophysical research communications, 2025, 742: Article 151060