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These effects are accompanied by reduced expression of proinflammatory cytokines (TNF- , IL-1, IL-6) and downregulation of RIP3, phosphorylated JNK, and c-Fos in the spinal cord, as well as an increased number of surviving neurons in the dorsal horn, indicating attenuation of CCI-induced neuronal death (121)

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Tau methylation can compete with other PTMs such as acetylation and ubiquitination