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Age As individuals age, their ability to absorb vitamin B12 diminishes, primarily due to decreased production of stomach acid or intrinsic factor, a protein necessary for B12 absorption

Pseudogenes of this locus have been identified on chromosomes X and 21

Its strict requirements and potential side effects necessitate careful consideration, professional guidance, and ongoing monitoring to ensure safety and efficacy[314]

Thus, targeting OXPHOS alone or in combination with other metabolic pathways could be an attractive therapeutic strategy to re-sensitise LSCs and AML blasts to conventional chemotherapeutic agents and improve AML patient outcomes