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Angle the needle against the vial wall and release the diluent slowly, letting it run down the glass rather than directly onto the lyophilized cake

doi: 10.1158/0008-5472.CAN-19-1405 9 KocinajAChaudhuryTUddinMSJunaidRRRamsdenDBHondhamuniGet al

The solvent Another possible cause of painful B12 injections is the solvent used to dissolve the B12 in the vial

Vitamin B12 deficiency manifests itself with the following common symptoms: Failure to grow in puppies and young dogs Weight loss Chronic diarrhea Vomiting Low red blood cell count (anemia) Weakness or other nervous system abnormalities Many of these are similar to symptoms seen in the digestive disorders which lead to B12 deficiency