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Kevin Klatt, PhD, RD, an assistant research scientist and instructor in the Department of Nutrition Sciences and Toxicology at University of California, Berkeley, cautions that epidemiological studies using circulating levels of nutrients or metabolites as proxies for dietary exposure often dont correlate with randomized controlled trials that aim to increase levels of those nutrients or metabolites

Specifically, in a clinical study it was shown that the additional intake at a dose of 1000 mg/day: [7] significantly reduced oxidative stress increased the activity of antioxidant enzymes in patients with coronary artery disease

Despus de la primera revisin de duplicidad se obtuvieron 52 estudios y, tras aplicar los criterios de inclusin y exclusin (Figura 1), 30 fueron rechazados por no ajustarse al tema de la revisin, 3 por no cumplir los criterios de inclusin al tratarse de revisiones, comentarios u otra tipologa documental y otros 2 porque la poblacin en estudio no eran RNPT (criterio de exclusin)

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