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The PRISMA 2020 flow diagram was generated using the PRISMA2020 R package and Shiny app (Haddaway et al
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Published online at OurWorldInData.org (2019)
Immunomodulation and Enhanced Immune Surveillance Aging is accompanied by a well-documented decline in immune function known as immunosenescence a state characterized by reduced T-cell proliferation, declining natural killer (NK) cell activity, and impaired antibody responses
