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Antibody and Biopharmaceutical Development Disulfide bond engineering has played a transformative role in antibody drug development

10.1080/14756366.2022.2117314 32 GongY.FanZ.LuoG.YangC.HuangQ.FanK.et al (2019)

flow rate 25 mL/min) to obtain BSO-OxMal (41 mg, 82%) as a white solid
