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Discovery of bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT)

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Such modulatory effects on cholesterol levels hint at its broader applicability, beyond just weight reduction, perhaps in the realm of metabolic health optimization [Usman et al., 2022]
Grip strength increased by approximately 60% when the compound was combined with rigorous exercise training, compared to about 25% improvement from either exercise or treatment alone
