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Knocking down PDIA4 significantly enhances sensitivity to chemotherapy drugs, suggesting it as a potential target for reversing drug resistance ( 5 Clinical applications and future prospects of disulfidptosis 5.1 Potential advantages over traditional biomarkers Biomarkers related to disulfidptosis, particularly SLC7A11, demonstrate unique advantages over traditional prostate-specific antigen (PSA) in the diagnosis of male urological cancers

However, LPCAT3 is not required for ferroptosis induction.31 Both, non-enzymatic (Fenton chemistry) and enzymatic (lipoxygenases, LOXs) mechanisms may trigger lipid peroxidation.33,34 However, the specific contribution of each mechanism is unclear and it may differ for different ferroptosis inducers.34 At which regulatory point iron contributes to ferroptosis is unclear

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