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Description
Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2 + -permeable -amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus

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The animals were kept in the Laboratory Animal Center of Shanghai Jiao Tong University and housed at 2125C, with 4050% humidity, a 12 h light:dark cycle, and free access to drinking water and standard feed

Treatment reduces circulating markers of metabolic dysfunction and inflammation, creating a more favorable metabolic environment that supports insulin sensitivity and glucose regulation
