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Its sequence does not conform to a typical signaling peptide motif, and it notably lacks a specific, high-affinity receptor identified to date

If not treated immediately, convulsions with simultaneous hypoxia, hypercarbia, and acidosis plus myocardial depression from the direct effects of the local anesthetic may result in cardiac arrhythmias, bradycardia, asystole, ventricular fibrillation, or cardiac arrest

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Similarly, anyone experiencing unexplained fatigue, weakness, neurological symptoms (such as numbness, tingling or problems with balance), or difficulty losing weight despite appropriate lifestyle measures should consult their GP