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Both Glo1 inducers and Glo1 inhibitors now offer the opportunity for important therapeutic advances in areas of unmet clinical need and major therapeutic impact

Nrf2 then translocates into the nucleus and binds to antioxidant response elements in the promoter region of several antioxidant genes, such as heme-oxygenase-1 and NADPH-quinone-oxidoreductase-1

Discovery of potent and selective rhodanine type IKKbeta inhibitors by hit-to-lead strategy

Apart from ibuprofen, the action of CYP2C9 on other target NSAIDs has been reported wherein diclofenac is metabolized to 4-hydroxydiclofenac, flurbiprofen is metabolized to 4-hydroxiflurbiprofen and naproxen is metabolized to 6-desmethylnaproxen [35]