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Adequate studies in humans have not been conducted
Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection
[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Shuto Y, Shibasaki T, Otagiri A, et al
[11] TMG can help replenish methyl groups and facilitate the clearance of nicotinamide, theoretically reducing the buildup of by-products that could cause fatigue or headaches in some individuals
