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Biochem Biophys Res Commun 309:578583 Shigemi Z, Manabe K, Hara N, Baba Y, Hosokawa K, Kagawa H, Watanabe T, Fujimuro M (2017) Methylseleninic acid and sodium selenite induce severe ER stress and subsequent apoptosis through UPR activation in PEL cells

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Cytotoxicity assays conducted on 3T3 fibroblasts, C2C12 myotubes, PC12 neurons, and RAW macrophages, demonstrated that neither Au nanospheres nor Au-PX-PLGA (0.010.5 mg/mL) caused significant toxicity, with cell viability remaining above 95%

The compact and symmetric structure of rosmarinic acid (Table 1) binds specifically to A, inhibits polymerization into the fibrillar form, and inhibits tau aggregation [170,173], imparting protection in AD and other neurogenerative conditions