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PCD affects three tissues/organs: the skeletal muscle, which develops myopathy, the central nervous system, which develops encephalopathy due to hypoketotic hypoglycemia

Treatment with L-Carnitine (300 mg/kg) and alpha-lipoic acid (100 mg/kg) for 28-30 days in aged rats restores activities of succinate dehydrogenase, malate dehydrogenase, -ketoglutarate dehydrogenase, isocitrate dehydrogenase, and respiratory complexes I-IV to near-normal levels, indicating enhanced mitochondrial energy-producing capacity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Chandler J, Cumpston M, Li T, Page MJ, Welch VJHW