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complement activation (2730)
Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates
According to evidence from post-mortem studies on patients with Parkinson's disease, synaptically coupled networks allow LP to spread from either the olfactory bulb or the dorsal motor nucleus of the vagus (DMV) in the caudal medulla to the substantia nigra pars compacta (SNpc) during the preclinical stages of the disease
165 LRP6 is downregulated in the AD brain, and deficiency in LRP6-mediated Wnt/-catenin signalling contributes to synaptic dysfunction and amyloid pathology in AD
