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[DOI] [PMC free article] [PubMed] [Google Scholar] 144.de Paula S, Vitola AS, Greggio S, de Paula D, Mello PB, Lubianca JM, Xavier LL, Fiori HH, Dacosta JC

glutathione deficiency directly inactivating GPX4, disabling phospholipid peroxide reduction

Some clear triggers to stop and contact a clinician include: New or worsening hypothyroid symptoms or an unexpected rise in TSH Unexplained INR instability if you are on warfarin New seizures or increased seizure frequency Evidence gaps and how clinicians can manage uncertainty Large randomized trials of supplement-drug interactions are rare

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