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Due to its ability to regulate membrane fluidity and stability, cholesterol is considered a crucial component in liposome formulation, serving as an important modulator of membrane permeability, elasticity, and stiffness in eukaryotic cell membranes, typically at 3050 mol % of the total lipid fraction (Jovanovi et al., 2018)

In terms of dietary patterns, the Mediterranean diet (MD) rich in various nutrients can be used as the basic pattern for OA patients due to its anti-inflammatory and anti-oxidative properties and good clinical effects

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