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Description
The premise underlying the leaky gut hypothesis is that physiologic stressors such as anxiety, intensive exercise, or dietary components such as emulsifiers increase intestinal mucosal paracellular permeability, enhancing entry of pathogenic bacteria and bacterial toxins into the systemic circulation, provoking systemic inflammation and triggering numerous diseases
Additionally, an overnight fasting period prior to ethanol administration was included in many of these studies, which likely altered GSH homeostasis [65, 66]
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Exposure to ROS dissociated Nrf2 from Keap1 and allowed relocation of Nrf2 to the nucleus, where ARE responsive genes became actively transcribed
